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kaiyun·开云(中国)

kaiyun·开云(中国)
瀛︽湳浜ゆ祦

娌冲寳澶у搴蜂箰銆侀檲鍏靛洟闃熸彮绀簃6A RNA淇グ璋冩帶椋炶潡鑱氶泦琛屼负鐨勫垎瀛愭満鍒迭/h1>

娣诲姞鏃堕棿锛?023-11-29 15:44:49   娴忚娆℃暟锛欬script>_showDynClicks("wbnews", 1914159992, 2182) 娆    銆 澶?/a> 涓?/a> 灏廃/a> 銆   鎵撳嵃   鍏抽棴绐楀彛

 

鍔ㄧ墿琛屼负鍙鎬э紙behavioral plasticity锛夛紝濡傜ぞ浼氭€х瓑绾у垎鍖栥€佽仛缇よ涓恒€佸涔犲拰璁板繂绛夛紝鏄姩鐗╁搷搴斿拰閫傚簲鐜鍙樺寲鐨勯噸瑕佹柟寮忋€傝涓哄彲濉戞€х殑璋冭妭鍏锋湁澶嶆潅鐨勫垎瀛愭満鍒讹紝鍏朵腑琛ㄨ淇グ鏈哄埗鍙兘鍦ㄤ笉鍚岃皟鎺ф按骞冲彂鎸ラ噸瑕佷綔鐢ㄣ€俁NA鑵哄槍鍛ょ殑N6-鐢插熀鍖栦慨楗帮紙m6ARNA modifications锛夋槸鐪熸牳鐢熺墿mRNA涓渶鏅亶鐨勪竴绉嶅唴閮ㄤ慨楗帮紝鍙互鐩存帴褰卞搷RNA鐨勫壀鎺ャ€佹垚鐔熴€佽浆杩愩€佺炕璇戞垨闄嶈В锛屽洜姝や篃鏄渶閲嶈鐨勮浆褰曞悗淇グ锛坧ost-transcriptionalmodification锛夊舰寮忎箣涓€銆俶6A淇グ浼氬奖鍝嶈澶氱敓鐗╁杩囩▼锛屽寘鎷彂鑲层€佷唬璋€佸厤鐤拰閫嗗鍝嶅簲锛屽湪鍔ㄧ墿琛屼负璋冭妭涓篃鍙兘鍙戞尌浣滅敤锛屼絾m6ARNA淇グ濡備綍褰卞搷琛屼负鍙鎬х殑鐮旂┒杈冨皯锛屽叾璋冭妭鍔ㄧ墿琛屼负鐨勫叿浣撴満鍒跺皻涓嶆竻妤氥€侟/p>

杩戞棩锛屾渤鍖楀ぇ瀛﹀悍涔愩€侀檲鍏垫暀鎺堝洟闃熷湪鐢熺墿瀛﹀浗闄呮湡鍒夵em>Science China-Life Science锛堜腑绉戦櫌涓€鍖簍op锛夊彂琛ㄤ簡棰樹负鈥淎 neural m6A pathway regulates behavioral aggregation in migratory locusts鈥濈殑鐮旂┒璁烘枃锛岀郴缁熼槓閲婁簡m6A RNA淇グ璋冩帶椋炶潡鑱氱兢琛屼负鍙鎬х殑鍒嗗瓙鏈哄埗锛屼负铦楃伨鍙戠敓鎻愪緵浜嗘柊鐨勮В閲娿€侟/p>

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鍥?m6A RNA淇グ璋冩帶椋炶潡鑱氱兢琛屼负

鎺ョ潃瀵圭敳鍩哄寲閰禡ETTL3銆丮ETTL14鍜屽幓鐢插熀鍖栭叾ALKBH5杩涜RNAi骞剁粨鍚堣涓哄娴嬭瘯锛屽彂鐜癿6A RNA淇グ鍙互鏈夋晥鍙€嗗湴璋冭妭椋炶潡鐨勮繍鍔ㄨ涓哄拰涓綋闂村惛寮曡涓猴紝璇佹槑璇NA淇グ鏄簿鍑嗚皟鎺ц仛闆嗚涓虹殑閲嶈鏈哄埗锛堝浘1锛夈€侟/p>

鎺ヤ笅鏉ラ€氳繃m6A-Seq鍜孯NA-Seq鑱斿悎鍒嗘瀽锛岃幏寰楄剳缁勭粐鍏ㄥ熀鍥犵粍姘村钩m6A鐢插熀鍖栦慨楗板浘璋憋紝瀵绘壘鍒板ぇ閲忓彈鐢插熀鍖栭叾璋冭妭瀵艰嚧m6A淇グ鏀瑰彉骞跺弬涓庨铦楄仛闆嗚涓鸿浆鍙樿皟鎺х殑鍩哄洜銆傛€讳綋涓婏紝鏁e眳鍨嬭緝缇ゅ眳鍨嬩釜浣撹〃鐜版洿楂樼殑m6A鐢插熀鍖栨按骞筹紝鑰岀敳鍩哄寲鎶戝埗浜嗗熀鍥犺〃杈俱€傝繘涓€姝ョ粨鍚堝畾閲廝CR楠岃瘉銆丷NAi鍜岃涓哄瀹為獙锛屽湪閲嶈鍙椾慨楗板熀鍥犱腑鍙戠幇涓€涓浆褰曞洜瀛愬熀鍥燣im3锛岃鍩哄洜鍝嶅簲绉嶇兢瀵嗗害鏀瑰彉鍙戠敓m6A鐢插熀鍖栧拰琛ㄨ揪鏀瑰彉锛屽苟璋冭妭浜嗕釜浣撶殑鑱氱兢琛屼负銆侟/p>

鏈爺绌舵槸璇ュ洟闃熷湪椋炶潡琛屼负鍙鎬х殑涓嶅悓璋冩帶鏈哄埗鐮旂┒涓紝缁ncRNA杞綍璋冭妭锛圥LoS Genet 2020锛孯NA Biol 2022)銆佸彲鍙樺壀鎺ヨ浆褰曞悗璋冭妭锛坋Life 2022锛夈€乻ulfation淇グ缈昏瘧鍚庤皟鑺?Nat Sci Rev 2022)鍙戠幇鍚庯紝鍦ㄨ浆褰曞悗璋冩帶姘村钩涓婄殑鏂板彂鐜般€傝鍙戠幇鏈夋湜鎸囧鐩稿叧琛ㄨ鍙鎬ф満鐞嗙爺绌讹紝骞朵績杩涜潡鐏惧彂鐢熸満鐞嗙殑鐞嗚В鍜岃潡鐏炬帶鍒剁瓥鐣ョ殑鍒跺畾銆侟/p>

娌冲寳澶у鐢熷懡绉戝瀛﹂櫌鏍¤仒鐮旂┒鍛橀粍璐や寒鍗氬+涓虹涓€浣滆€咃紝闄堝叺鏁欐巿鍜屽悍涔愰櫌澹负鍏卞悓閫氳浣滆€呫€傝宸ヤ綔寰楀埌浜嗕腑鍥界瀛﹂櫌鍩哄洜缁勭爺绌舵墍鏉ㄤ簯妗傜爺绌跺憳鐨勫叏绋嬫寚瀵硷紝鍙楀埌浜嗗浗瀹惰嚜鐒剁瀛﹀熀閲戙€佸浗瀹堕噸鐐圭爺鍙戣鍒掑拰娌冲寳鐪佽嚜鐒剁瀛﹀熀閲戠殑璧勫姪銆侟/p>

鍏ㄦ枃閾炬帴锛欬a href="http://engine.scichina.com/doi/10.1007/s11427-023-2476-1">http://engine.scichina.com/doi/10.1007/s11427-023-2476-1

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